5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT).
In Central and South America, some of the best known 5-MeO-DMT sources are Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff. It’s also found in the milky white venom of the Colorado river toad(Bufo alvarius/Incilius alvarius) native to the southwestern United States and northwestern Mexico.
In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. Many people also find its effects to be personally useful or even life changing.
Description of 5-Meo-DMT
5-MeO-DMT—short for 5-Methoxy-N,N-Dimethyltryptamine—looks just like DMT on both a macro and micro level, with a few extra atoms attached (which is what “5-MeO” in the name tells us). That slight change makes all the difference, though.
Like DMT, 5-MeO-DMT also appears in many plants and animals—including the venom of a particular toad—but has not been found in humans. While the DMT experience tends to be highly visual, 5-MeO-DMT is more like a perspective shift. Some have said it’s something like a near-death experience.
5-MeO-DMT has a traditional, shamanic use as well, in the form of a powerful “yopo,” or powder blown forcefully into the nose. Being somewhat more obscure than DMT, the potential of 5-MeO-DMT for healing substance addiction is less well known, but some progressive treatment centers have found it extremely useful.
One such is the cross road treatment centers in Northern Mexico, which specializes in combination ibogaine and 5-MeO-DMT therapy. 5-MeO-DMT seems to work synergistically with the ibogaine, by allowing patients to integrate the ibogaine with a transcendental or mystical experience. It helps patients re-contextualize their experience and ultimately can give them inspiration and motivation.